CRB1 antibody (C-Term) (Fluoro488)

Catalog No. ABIN7981857

This Rabbit Polyclonal antibody specifically detects CRB1 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CRB1 antibody (C-Term) (Fluoro488) (ABIN7981857)

Target: CRB1 (Crumbs Homolog 1 (CRB1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRB1 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-CRB1 Antibody (Fluoro488)

Binding Specificity: C-Term

Purpose: Anti-CRB1 Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CRB1, which shares 87.9% and 84.8% amino acid (aa) sequence identity with mouse and rat CRB1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CRB1

Target: CRB1 (Crumbs Homolog 1 (CRB1))

Alternative Name: CRB1

Background:

Background: Crumbs homolog 1 is a protein that in humans is encoded by the CRB1 gene. This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.

Gene Full Name: crumbs cell polarity complex component 1

Gene ID: 23418

UniProt: P82279

Pathways: Notch Signaling