DCLK1 antibody (AA 1-728) (Fluoro594)

Catalog No. ABIN7986300

This Rabbit Polyclonal antibody specifically detects DCLK1 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for DCLK1 antibody (AA 1-728) (Fluoro594) (ABIN7986300)

Target: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCLK1 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-DCLK1 Antibody (Fluoro594)

Binding Specificity: AA 1-728

Purpose: Anti-DCLK1 Antibody Fluoro594 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human DCLK1 shares 96.4% amino acid (aa) sequence identity with mouse DCLK1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human DCLK1 recombinant protein (Position: M1-S728). Human DCLK1 shares 96.4% amino acid (aa) sequence identity with mouse DCLK1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for DCLK1

Target: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Alternative Name: DCLK1

Background:

Background: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.

Gene Full Name: doublecortin like kinase 1

Gene ID: 9201

UniProt: O15075