FBXW7 antibody (AA 151-591) (PE)

Catalog No. ABIN7989450

This Rabbit Polyclonal antibody specifically detects FBXW7 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for FBXW7 antibody (AA 151-591) (PE) (ABIN7989450)

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW7 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-FBXW7 Antibody (PE)

Binding Specificity: AA 151-591

Purpose: Anti-FBXW7 Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human FBXW7 shares 99.3%,98.9% amino acid (aa) sequence identity with mouse,rat FBXW7,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FBXW7 recombinant protein (Position: D151-D591). Human FBXW7 shares 99.3% and 98.9% amino acid (aa) sequence identity with mouse and rat FBXW7, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for FBXW7

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Alternative Name: FBXW7

Background:

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class, in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: F-box and WD repeat domain containing 7

Gene ID: 55294

UniProt: Q969H0

Pathways: Notch Signaling, EGFR Signaling Pathway