FKBP15 antibody (AA 19-1210) (Fluoro488)

Catalog No. ABIN7990954

The Rabbit Polyclonal anti-FKBP15 antibody is suitable to detect FKBP15 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for FKBP15 antibody (AA 19-1210) (Fluoro488) (ABIN7990954)

Target: FKBP15 (FK506 Binding Protein 15, 133kDa (FKBP15))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FKBP15 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-FKBP15 Antibody (Fluoro488)

Binding Specificity: AA 19-1210

Purpose: Anti-FKBP135/FKBP15 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FKBP135/FKBP15 recombinant protein (Position: A19-D1210).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for FKBP15

Target: FKBP15 (FK506 Binding Protein 15, 133kDa (FKBP15))

Alternative Name: FKBP15

Background:

Background: FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins, targets for the immunosupressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif. FKBP15 is distributed along the axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons, overexpression of FKBP15 resulted in the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 has also been shown to associate with both microtubules and the actin filament systems and disruption of its expression by RNAi resulted in delayed transport of early endosomes in HeLa cells indicating that FKBP15 is also involved in the transport of early endosomes. At least three isoforms of FKBP15 are known to exist.

Gene Full Name: FKBP prolyl isomerase family member 15

Gene ID: 23307

UniProt: Q5T1M5

Pathways: SARS-CoV-2 Protein Interactome