FLT3 antibody (AA 62-295) (Fluoro594)

Catalog No. ABIN7991187

This Rabbit Polyclonal antibody specifically detects FLT3 in FACS. It exhibits reactivity toward Mouse and Rat.

Quick Overview for FLT3 antibody (AA 62-295) (Fluoro594) (ABIN7991187)

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FLT3 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-FLT3 Antibody (Fluoro594)

Binding Specificity: AA 62-295

Purpose: Anti-Flt3/CD135 Antibody Fluoro594 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived mouse Flt3 / CD135 recombinant protein (Position: E62-E295).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for FLT3

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Alternative Name: Flt3

Background:

Background: Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow.

Gene Full Name: FMS-like tyrosine kinase 3

Gene ID: 14255

UniProt: Q00342

Pathways: RTK Signaling