GZMB antibody (AA 21-247) (Fluoro488)

Catalog No. ABIN7995044

The Fluoro488-conjugated Rabbit Polyclonal anti-GZMB antibody (ABIN7995044) specifically detects GZMB in FACS. The antibody is reactive with Mouse and Rat samples.

Quick Overview for GZMB antibody (AA 21-247) (Fluoro488) (ABIN7995044)

Target: GZMB (Granzyme B (GZMB))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GZMB antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-GZMB Antibody (Fluoro488)

Binding Specificity: AA 21-247

Purpose: Anti-Granzyme B/Gzmb Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived mouse Granzyme B recombinant protein (Position: I21-S247).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for GZMB

Target: GZMB (Granzyme B (GZMB))

Alternative Name: Gzmb

Background:

Background: Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

Gene Full Name: granzyme B

Gene ID: 14939

UniProt: P04187

Pathways: Apoptosis, Caspase Cascade in Apoptosis