Integrin Alpha2b antibody (C-Term) (Cy3)

Catalog No. ABIN8000463

The Rabbit Polyclonal anti-Integrin Alpha2b antibody is suitable to detect Integrin Alpha2b in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for Integrin Alpha2b antibody (C-Term) (Cy3) (ABIN8000463)

Target: Integrin Alpha2b (CD41)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Integrin Alpha2b antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-Integrin Alpha2b Antibody (Cy3)

Binding Specificity: C-Term

Purpose: Anti-CD41/Integrin alpha 2b/ITGA2B Antibody Cy3 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related mouse sequence by four amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human ITGA2B, different from the related mouse sequence by four amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Alternative Name: ITGA2B

Background:

Background: Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. It is mapped to 17q21.32. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Gene Full Name: integrin subunit alpha 2b

Sequence Similarities: Contains 1 HMG box DNA-binding domain.

Gene ID: 3674

UniProt: P08514

Pathways: Integrin Complex