IL-21 antibody (AA 18-146)

Catalog No. ABIN8002320

The Rabbit Polyclonal anti-IL-21 antibody is suitable to detect IL-21 in samples from Mouse and Rat. It has been validated for ELISA and IHC.

Quick Overview for IL-21 antibody (AA 18-146) (ABIN8002320)

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-21 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Grade: Carrier-free

Product Details anti-IL-21 Antibody

Binding Specificity: AA 18-146

Purpose: Anti-IL-21/Il21 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-IL-21/Il21 Antibody. Tested in ELISA, IHC applications. This antibody reacts with Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse IL-21/Il21 recombinant protein (Position: H18-S146).

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.005 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for IL-21

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Alternative Name: Il21

Background:

Background: Interleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene. This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene Full Name: interleukin 21

Molecular Weight: 65-80 kDa

Gene ID: 60505

UniProt: Q9ES17

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response