JAG2 antibody (AA 22-1153) (Cy3)

Catalog No. ABIN8003576

This Rabbit Polyclonal antibody specifically detects JAG2 in FACS. It exhibits reactivity toward Human.

Quick Overview for JAG2 antibody (AA 22-1153) (Cy3) (ABIN8003576)

Target: JAG2 (Jagged 2 (JAG2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JAG2 antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-JAG2 Antibody (Cy3)

Binding Specificity: AA 22-1153

Purpose: Anti-Jagged 2/JAG2 Antibody Cy3 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human JAG2 shares 91.1%,91% amino acid (aa) sequence identity with mouse,rat JAG2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Jagged 2/JAG2 recombinant protein (Position: Q22-N1153). Human JAG2 shares 91.1% and 91% amino acid (aa) sequence identity with mouse and rat JAG2, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for JAG2

Target: JAG2 (Jagged 2 (JAG2))

Alternative Name: JAG2

Background:

Background: Protein jagged-2, also known as SER2, is a protein that in humans is encoded by the JAG2 gene. It is mapped to 14q32.33. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Notch ligands Delta1 and JAG2 are subject to presenilin-dependent, intramembranous gamma-secretase processing, resulting in the production of soluble intracellular derivatives. JAG2 can promote the growth and dissemination of uveal melanoma cells.

Gene Full Name: jagged canonical Notch ligand 2

Gene ID: 3714

UniProt: Q9Y219

Pathways: Notch Signaling, Sensory Perception of Sound