JAG2 antibody (AA 22-1153) (HRP)

Catalog No. ABIN8003581

The HRP-conjugated Rabbit Polyclonal anti-JAG2 antibody (ABIN8003581) specifically detects JAG2 in WB, IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for JAG2 antibody (AA 22-1153) (HRP) (ABIN8003581)

Target: JAG2 (Jagged 2 (JAG2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JAG2 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-JAG2 Antibody (HRP)

Binding Specificity: AA 22-1153

Purpose: Anti-Jagged 2/JAG2 Antibody HRP Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human JAG2 shares 91.1%,91% amino acid (aa) sequence identity with mouse,rat JAG2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Jagged 2/JAG2 recombinant protein (Position: Q22-N1153). Human JAG2 shares 91.1% and 91% amino acid (aa) sequence identity with mouse and rat JAG2, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for JAG2

Target: JAG2 (Jagged 2 (JAG2))

Alternative Name: JAG2

Background:

Background: Protein jagged-2, also known as SER2, is a protein that in humans is encoded by the JAG2 gene. It is mapped to 14q32.33. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Notch ligands Delta1 and JAG2 are subject to presenilin-dependent, intramembranous gamma-secretase processing, resulting in the production of soluble intracellular derivatives. JAG2 can promote the growth and dissemination of uveal melanoma cells.

Gene Full Name: jagged canonical Notch ligand 2

Gene ID: 3714

UniProt: Q9Y219

Pathways: Notch Signaling, Sensory Perception of Sound