JAG2 antibody (AA 22-1153)

Catalog No. ABIN8003585

This Rabbit Polyclonal antibody specifically detects JAG2 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for JAG2 antibody (AA 22-1153) (ABIN8003585)

Target: JAG2 (Jagged 2 (JAG2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JAG2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Grade: Carrier-free

Product Details anti-JAG2 Antibody

Binding Specificity: AA 22-1153

Purpose: Anti-Jagged 2/JAG2 Antibody

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human JAG2 shares 91.1%,91% amino acid (aa) sequence identity with mouse,rat JAG2,respectively.

Characteristics: Anti-Jagged 2/JAG2 Antibody. Tested in ELISA, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Jagged 2/JAG2 recombinant protein (Position: Q22-N1153). Human JAG2 shares 91.1% and 91% amino acid (aa) sequence identity with mouse and rat JAG2, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for JAG2

Target: JAG2 (Jagged 2 (JAG2))

Alternative Name: JAG2

Background:

Background: Protein jagged-2, also known as SER2, is a protein that in humans is encoded by the JAG2 gene. It is mapped to 14q32.33. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Notch ligands Delta1 and JAG2 are subject to presenilin-dependent, intramembranous gamma-secretase processing, resulting in the production of soluble intracellular derivatives. JAG2 can promote the growth and dissemination of uveal melanoma cells.

Gene Full Name: jagged canonical Notch ligand 2

Molecular Weight: 130 kDa

Gene ID: 3714

UniProt: Q9Y219

Pathways: Notch Signaling, Sensory Perception of Sound