MCU antibody (AA 51-351) (Biotin)

Catalog No. ABIN8010641

This Rabbit Polyclonal antibody specifically detects MCU in ELISA, IHC and WB. It exhibits reactivity toward Human, Mouse, Rat and Monkey.

Quick Overview for MCU antibody (AA 51-351) (Biotin) (ABIN8010641)

Target: MCU (Mitochondrial Calcium Uniporter (MCU))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCU antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Product Details anti-MCU Antibody (Biotin)

Binding Specificity: AA 51-351

Purpose: Anti-MCU Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MCU recombinant protein (Position: V51-D351).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MCU

Target: MCU (Mitochondrial Calcium Uniporter (MCU))

Alternative Name: MCU

Background:

Background: The mitochondrial calcium uniporter (MCU) is a transmembrane protein that allows the passage of calcium ions from a cell's cytosol into mitochondria. Its activity is regulated by MICU1 and MICU2, which together with the MCU make up the mitochondrial calcium uniporter complex. This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants.

Gene Full Name: mitochondrial calcium uniporter

Gene ID: 90550

UniProt: Q8NE86

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis