MUS81 antibody (AA 6-545) (Fluoro647)

Catalog No. ABIN8012080

The Fluoro647-conjugated Rabbit Polyclonal anti-MUS81 antibody (ABIN8012080) specifically detects MUS81 in FACS. The antibody is reactive with Human and Rat samples.

Quick Overview for MUS81 antibody (AA 6-545) (Fluoro647) (ABIN8012080)

Target: MUS81 (MUS81 Endonuclease Homolog (MUS81))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUS81 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-MUS81 Antibody (Fluoro647)

Binding Specificity: AA 6-545

Purpose: Anti-MUS81 Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MUS81 recombinant protein (Position: R6-C545).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MUS81

Target: MUS81 (MUS81 Endonuclease Homolog (MUS81))

Alternative Name: MUS81

Background:

Background: Crossover junction endonuclease MUS81 is an enzyme that in humans is encoded by the MUS81 gene. This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks.

Gene Full Name: MUS81 structure-specific endonuclease subunit

Gene ID: 80198

UniProt: Q96NY9

Pathways: DNA Damage Repair