NOD1 antibody (C-Term)

Catalog No. ABIN8017596

The Rabbit Polyclonal anti-NOD1 antibody is suitable to detect NOD1 in samples from Monkey. It has been validated for WB.

Quick Overview for NOD1 antibody (C-Term) (ABIN8017596)

Target: NOD1 (Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1))

Reactivity: Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOD1 antibody is un-conjugated

Application: Western Blotting (WB)

Grade: Carrier-free

Product Details anti-NOD1 Antibody

Binding Specificity: C-Term

Purpose: Anti-CARD4/NOD1 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-CARD4/NOD1 Antibody. Tested in WB applications. This antibody reacts with Monkey.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CARD4/NOD1, which shares 88.2% and 93.8% amino acid (aa) sequence identity with mouse and rat CARD4/NOD1, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Monkey

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NOD1

Target: NOD1 (Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1))

Alternative Name: NOD1

Background:

Background: Nucleotide-binding oligomerization domain-containing protein 1, also known as CARD4, is a protein receptor that in humans is encoded by the NOD1 gene. NOD1 is a member of NOD-like receptor protein family and is a close relative of NOD2. NOD1 is mapped to 7p14.3. It recognizes bacterial molecules and stimulates an immune reaction. NOD1 protein contains a caspase recruitment domain (CARD). This gene is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants, and mediates innate and acquired immunity by recognizing bacterial molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety. What wore, it has been shown that NOD1 can sense cytosolic microbial products by monitoring the activation state of small Rho GTPases.

Gene Full Name: nucleotide binding oligomerization domain containing 1

Molecular Weight: 108 kDa

Gene ID: 10392

UniProt: Q9Y239

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades, Inflammasome