PON1 antibody (Middle Region) (Fluoro647)

Catalog No. ABIN8019557

This Rabbit Polyclonal antibody specifically detects PON1 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PON1 antibody (Middle Region) (Fluoro647) (ABIN8019557)

Target: PON1 (Paraoxonase 1 (PON1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PON1 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-PON1 Antibody (Fluoro647)

Binding Specificity: Middle Region

Purpose: Anti-PON1 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related mouse,rat sequences by three amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human PON1, different from the related mouse and rat sequences by three amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PON1

Target: PON1 (Paraoxonase 1 (PON1))

Alternative Name: PON1

Background:

Background: Serum paraoxonase/arylesterase 1 (PON1), also known as aromatic esterase 1, is an enzyme that in humans is encoded by the PON1 gene. It is mapped to 7q21.3. This gene has esterase and more specifically paraoxonase activity. PON1 is responsible for hydrolysing organophosphate pesticides and nerve gasses. Polymorphisms in the PON1 gene significantly affect the catalytic ability of the enzyme. PON1 (paraoxonase 1) is also a major anti-atherosclerotic component of high-density lipoprotein (HDL). The PON1 gene is activated by PPAR-gamma, which increases synthesis and release of paraoxonase 1 enzyme from the liver, reducing atherosclerosis.

Gene Full Name: paraoxonase 1

Sequence Similarities: Belongs to the paraoxonase family.

Gene ID: 5444

UniProt: P27169