PFKM antibody (AA 39-780) (PE)

Catalog No. ABIN8021622

The Rabbit Polyclonal anti-PFKM antibody is suitable to detect PFKM in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for PFKM antibody (AA 39-780) (PE) (ABIN8021622)

Target: PFKM (phosphofructokinase, Muscle (PFKM))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PFKM antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-PFKM Antibody (PE)

Binding Specificity: AA 39-780

Purpose: Anti-PFKM Antibody PE Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human PFKM shares 97.7%,96.8% amino acid (aa) sequence identity with mouse,rat PFKM,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PFKM recombinant protein (Position: R39-V780). Human PFKM shares 97.7% and 96.8% amino acid (aa) sequence identity with mouse and rat PFKM, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PFKM

Target: PFKM (phosphofructokinase, Muscle (PFKM))

Alternative Name: PFKM

Background:

Background: 6-phosphofructokinase, muscle type is an enzyme that in humans is encoded by the PFKM gene on chromosome 12. Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.

Gene Full Name: phosphofructokinase, muscle

Gene ID: 5213

UniProt: P08237

Pathways: Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Warburg Effect