PLCE1 antibody (AA 4-735) (PE)

Catalog No. ABIN8022177

The Rabbit Polyclonal anti-PLCE1 antibody is suitable to detect PLCE1 in samples from Human. It has been validated for FACS.

Quick Overview for PLCE1 antibody (AA 4-735) (PE) (ABIN8022177)

Target: PLCE1 (Phospholipase C, epsilon 1 (PLCE1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLCE1 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-PLCE1 Antibody (PE)

Binding Specificity: AA 4-735

Purpose: Anti-PLCE1 Antibody PE Conjugated

Predicted Reactivity: Human PLCE1 shares 74.6%,73.6% amino acid (aa) sequence identity with mouse,rat PLCE1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PLCE1 recombinant protein (Position: E4-E735). Human PLCE1 shares 74.6% and 73.6% amino acid (aa) sequence identity with mouse and rat PLCE1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PLCE1

Target: PLCE1 (Phospholipase C, epsilon 1 (PLCE1))

Alternative Name: PLCE1

Background:

Background: Phospholipase C epsilon 1 (PLCE1) is an enzyme that in humans is encoded by the PLCE1 gene. This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome, characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene Full Name: phospholipase C epsilon 1

Gene ID: 51196

UniProt: Q9P212

Pathways: EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling