Tec Protein Tyrosine Kinase (TEC) (C-Term) antibody (Fluoro488)

Catalog No. ABIN8045631

The Rabbit Polyclonal anti-Tec Protein Tyrosine Kinase antibody is suitable to detect Tec Protein Tyrosine Kinase in samples from Human and Rat. It has been validated for FACS.

Quick Overview for Tec Protein Tyrosine Kinase (TEC) (C-Term) antibody (Fluoro488) (ABIN8045631)

Target: Tec Protein Tyrosine Kinase (TEC)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Fluoro488

Application: Flow Cytometry (FACS)

Product Details

Binding Specificity: C-Term

Purpose: Anti-Tyrosine-protein kinase Tec Tec Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: identical to the related rat sequence,and different from the related mouse sequence by one amino acid.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Tec, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details

Target: Tec Protein Tyrosine Kinase (TEC)

Alternative Name: TEC

Background:

Background: TEC (TEC Protein Tyrosine Kinase), is an enzyme that in humans is encoded by the TEC gene. The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. By fluorescence in situ hybridization, Sato et al. (1994) mapped the gene to 4p12, the same location reported for TXK. Mouse Tec is a non-receptor type protein-tyrosine kinase that is highly expressed in many hematopoietic cell lines. Hantschel et al. (2007) identified TEC kinase and BTK kinase as major binders of the tyrosine kinase inhibitor dasatinib, which is used for treatment of BCR/ABL-positive CML.

Gene Full Name: tec protein tyrosine kinase

Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.

Gene ID: 7006

UniProt: P42680

Pathways: Fc-epsilon Receptor Signaling Pathway