WFS1 antibody (AA 61-313) (PE)

Catalog No. ABIN8054499

The Rabbit Polyclonal anti-WFS1 antibody is suitable to detect WFS1 in samples from Human and Monkey. It has been validated for FACS.

Quick Overview for WFS1 antibody (AA 61-313) (PE) (ABIN8054499)

Target: WFS1 (Wolfram Syndrome 1 (WFS1))

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WFS1 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-WFS1 Antibody (PE)

Binding Specificity: AA 61-313

Purpose: Anti-WFS1 Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human WFS1 recombinant protein (Position: A61-H313).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for WFS1

Target: WFS1 (Wolfram Syndrome 1 (WFS1))

Alternative Name: WFS1

Background:

Background: Wolframin is a protein that in humans is encoded by the WFS1 gene. This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene.

Gene Full Name: wolframin ER transmembrane glycoprotein

Gene ID: 7466

UniProt: O76024

Pathways: Sensory Perception of Sound, Carbohydrate Homeostasis, ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome