CD46 antibody (AA 10-90)

Catalog No. ABIN8120384

This Rabbit Polyclonal antibody specifically detects CD46 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CD46 antibody (AA 10-90) (ABIN8120384)

Target: CD46

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD46 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CD46 Antibody

Binding Specificity: AA 10-90

Purpose: MCP Antibody

Specificity: MCP Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human protein . at AA range: 10-90

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for CD46

Target: CD46

Alternative Name: MCP

Background:

Background: The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally,The protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010],

Gene Name: CD46 MCP MIC10

Protein Name: Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46)

Gene ID: 4179

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization