CDKN1C antibody (AA 200-316)

Catalog No. ABIN8120826

The Rabbit Monoclonal anti-CDKN1C antibody is suitable to detect CDKN1C in samples from Human. It has been validated for IHC.

Quick Overview for CDKN1C antibody (AA 200-316) (ABIN8120826)

Target: CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CDKN1C antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: AB1475

Product Details anti-CDKN1C Antibody

Binding Specificity: AA 200-316

Purpose: p57kip2 Rabbit mAb

Specificity: This antibody detects endogenous levels of p57kip2 (ABT76R) rabbit mAb protein.

Purification: The antibody was purified by protein A affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 200 - 316 of the human p57kip2.

Isotype: IgG

Application Details

Application Notes: WB, 1:500-1:2000 | IHC, 1:50-1:200 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for CDKN1C

Target: CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))

Alternative Name: p57kip2

Background:

Synonyms: CDKN1C, KIP2, Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57Kip2

Background: This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Gene Name: CDKN1C

Protein Name: p57kip2 (ABT76R) rabbit mAb

Gene ID: 1028

UniProt: P49918

Pathways: Cell Division Cycle, Dopaminergic Neurogenesis