CYFIP2 antibody (AA 1171-1220)

Catalog No. ABIN8120893

The Rabbit Polyclonal anti-CYFIP2 antibody (ABIN8120893) specifically detects CYFIP2 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for CYFIP2 antibody (AA 1171-1220) (ABIN8120893)

Target: CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2 (CYFIP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYFIP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CYFIP2 Antibody

Binding Specificity: AA 1171-1220

Purpose: CYFIP2 Antibody

Specificity: CYFIP2 Polyclonal Antibody detects endogenous levels of CYFIP2

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from CYFIP2 at AA range: 1171-1220

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000, ELISA 1:10000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for CYFIP2

Target: CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2 (CYFIP2))

Alternative Name: CYFIP2

Background:

Synonyms: Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)

Background: disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level).,function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA.,induction:By p53.,RNA editing:Partially edited. Editing appears to be brain-specific.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.,subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,

Gene Name: CYFIP2

Protein Name: CYFIP2

Gene ID: 26999

UniProt: Q96F07

Pathways: RTK Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity