Huntingtin antibody (acLys442)

Catalog No. ABIN8122113

The Rabbit Polyclonal anti-Huntingtin antibody is suitable to detect Huntingtin in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for Huntingtin antibody (acLys442) (ABIN8122113)

Target: Huntingtin (HTT)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Huntingtin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Huntingtin Antibody

Binding Specificity: acLys442

Purpose: Huntingtin (Acetyl Lys442) Antibody

Specificity: This antibody detects endogenous levels of Human,Mouse,Rat Huntingtin (Acetyl Lys442)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human Huntingtin (Acetyl Lys442)

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Huntingtin

Target: Huntingtin (HTT)

Alternative Name: Huntingtin

Background:

Synonyms: Huntingtin (Huntington disease protein; HD protein)

Background: huntingtin(HTT) Homo sapiens Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widel

Gene Name: HTT HD IT15

Protein Name: Huntingtin (Acetyl Lys442)

Gene ID: 3064

UniProt: P42858

Pathways: PI3K-Akt Signaling, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport