MAP3K11 antibody (pSer281, pThr277)

Catalog No. ABIN8123016

The Rabbit Polyclonal anti-MAP3K11 antibody is suitable to detect MAP3K11 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IHC.

Quick Overview for MAP3K11 antibody (pSer281, pThr277) (ABIN8123016)

Target: MAP3K11 (Mitogen-Activated Protein Kinase Kinase Kinase 11 (MAP3K11))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K11 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-MAP3K11 Antibody

Binding Specificity: pSer281, pThr277

Purpose: MLK3 (Phospho Thr277+Ser281) Antibody

Specificity: This antibody detects endogenous levels of Human,Mouse,Rat MLK3 (Phospho Thr277+Ser281)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human MLK3 (Phospho Thr277+Ser281)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for MAP3K11

Target: MAP3K11 (Mitogen-Activated Protein Kinase Kinase Kinase 11 (MAP3K11))

Alternative Name: MLK3

Background:

Synonyms: Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase)

Background: The protein encoded byThis gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008],

Gene Name: MAP3K11 MLK3 PTK1 SPRK

Protein Name: MLK3 (Phospho Thr277+Ser281)

Gene ID: 4296

UniProt: Q16584

Pathways: MAPK Signaling, Interferon-gamma Pathway