PDE3A antibody (pSer312)

Catalog No. ABIN8123720

This Rabbit Polyclonal antibody specifically detects PDE3A in WB. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for PDE3A antibody (pSer312) (ABIN8123720)

Target: PDE3A (phosphodiesterase 3A, cGMP-Inhibited (PDE3A))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE3A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDE3A Antibody

Binding Specificity: pSer312

Purpose: PDE3A (Phospho Ser312) Antibody

Specificity: This antibody detects endogenous levels of PDE3A (Phospho-Ser312) at Human, Mouse,Rat

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human PDE3A (Phospho-Ser312)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PDE3A

Target: PDE3A (phosphodiesterase 3A, cGMP-Inhibited (PDE3A))

Alternative Name: PDE3A

Background:

Synonyms: cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A)

Background: This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011],

Gene Name: PDE3A

Protein Name: PDE3A (Phospho-Ser312)

Gene ID: 5139

UniProt: Q14432

Pathways: cAMP Metabolic Process