ALIX antibody (AA 410-490)

Catalog No. ABIN8123959

The Rabbit Polyclonal anti-ALIX antibody (ABIN8123959) specifically detects ALIX in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for ALIX antibody (AA 410-490) (ABIN8123959)

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALIX antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ALIX Antibody

Binding Specificity: AA 410-490

Purpose: Alix Antibody

Specificity: This antibody detects endogenous levels of human Alix

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Alix AA range: 410-490

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000, ELISA(peptide)1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for ALIX

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Alternative Name: Alix

Background:

Synonyms: Programmed cell death 6-interacting protein (PDCD6-interacting protein, ALG-2-interacting protein 1, Hp95)

Background: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012],

Gene Name: PDCD6IP AIP1 ALIX KIAA1375

Protein Name: Alix

Gene ID: 10015

UniProt: Q8WUM4

Pathways: p53 Signaling, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation