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BMI1 antibody
BMI1
Reactivity: Human
WB, ELISA
Host: Mouse
Monoclonal
unconjugated
Product Details anti-BMI1 Antibody
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Target
See all BMI1 Antibodies
BMI1
(BMI1 Polycomb Ring Finger Oncogene (BMI1))
Reactivity
All reactivities for BMI1 antibodies
Human
Host
All hosts for BMI1 antibodies
Mouse
Clonality
All clonalities for BMI1 antibodies
Monoclonal
Conjugate
All conjugates for BMI1 antibodies
This BMI1 antibody is un-conjugated
Application
All applications for BMI1 antibodies
Western Blotting (WB), ELISA
Specificity
Nucleus
Purification
Protein G-Sepharose affinity purified
Immunogen
Synthetic peptide from the N-terminal region of human Bmi1, conjugated to KLH.
Isotype
IgG
Top Product
Discover our top product BMI1 Primary Antibody
Alternatives
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Application Details
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Application Notes
Recommended dilutions. ELISA: 1/5000 - 1/20000. WB: 1/100-1/2000.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
50µg/50µl
Buffer
0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Target Details for BMI1
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Target
BMI1
(BMI1 Polycomb Ring Finger Oncogene (BMI1))
Alternative Name
Bmi1 (BMI1 Products )
Synonyms
FLVI2/BMI1 antibody, PCGF4 antibody, RNF51 antibody, AW546694 antibody, Bmi-1 antibody, Pcgf4 antibody, bmi1 antibody, pcgf4 antibody, psc1 antibody, wu:fb17g03 antibody, wu:fd18f06 antibody, BMI-1 antibody, pcgf4b antibody, bmi-1 antibody, bmi1-a antibody, bmi1-b antibody, bmi1b antibody, rnf51 antibody, xbmi-1 antibody, BMI1 proto-oncogene, polycomb ring finger antibody, BMI1 polycomb ring finger oncogene antibody, Bmi1 polycomb ring finger oncogene antibody, bmi1 polycomb ring finger oncogene 1a antibody, bmi1 polycomb ring finger oncogene 1b antibody, BMI1 proto-oncogene, polycomb ring finger L homeolog antibody, BMI1 antibody, LOC100230513 antibody, Bmi1 antibody, bmi1a antibody, bmi1b antibody, bmi1.L antibody
Background
The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation.
Molecular Weight
37kDa
NCBI Accession
NM_005180
Pathways
Cell Division Cycle , Autophagy
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