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NLRP7 antibody (N-Term)

NLRP7 Reactivity: Human WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN783711
  • Target See all NLRP7 Antibodies
    NLRP7 (NLR Family, Pyrin Domain Containing 7 (NLRP7))
    Binding Specificity
    • 15
    • 5
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    Human
    Host
    • 23
    • 1
    Rabbit
    Clonality
    • 24
    Polyclonal
    Conjugate
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NLRP7 antibody is un-conjugated
    Application
    • 17
    • 13
    • 13
    • 9
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects NLRP7 at N-term.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    18 amino acid peptide near the amino terminus of human NALP7
    Top Product
    Discover our top product NLRP7 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
  • Target
    NLRP7 (NLR Family, Pyrin Domain Containing 7 (NLRP7))
    Alternative Name
    NLRP7 (NLRP7 Products)
    Synonyms
    CLR19.4 antibody, HYDM antibody, NALP7 antibody, NOD12 antibody, PAN7 antibody, PYPAF3 antibody, NLR family pyrin domain containing 7 antibody, NLRP7 antibody
    Background
    NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1beta secretion and is a feedback regulator of interleukin-1beta secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.Synonyms: LRR and PYD domains-containing protein 7, NALP7, NOD12, Nucleotide-binding oligomerization domain protein 12, PYPAF3, PYRIN-containing APAF1-like protein 3
    Gene ID
    199713
    NCBI Accession
    NP_001120727
    UniProt
    Q8WX94
    Pathways
    Inflammasome
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