NLRP7 antibody (N-Term)

Catalog No. ABIN6991404

Product Details anti-NLRP7 Antibody

Target: NLRP7 (NLR Family, Pyrin Domain Containing 7 (NLRP7))

Binding Specificity: AA 90-140, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP7 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: NALP7 Antibody is affinity chromatography purified via peptide column.

Immunogen: NALP7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP7. The immunogen is located within amino acids 90 - 140 of NALP7.

Isotype: IgG

Application Details

Application Notes: NALP7 antibody can be used for detection of NALP7 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: NALP7 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: NALP7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for NLRP7

Target: NLRP7 (NLR Family, Pyrin Domain Containing 7 (NLRP7))

Alternative Name: NALP7 (NLRP7 Products)

Synonyms: CLR19.4 antibody, HYDM antibody, NALP7 antibody, NOD12 antibody, PAN7 antibody, PYPAF3 antibody, NLR family pyrin domain containing 7 antibody, NLRP7 antibody

Background: NALP7 Antibody: NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1β, secretion and is a feedback regulator of interleukin-1β, secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.

Gene ID: 199713

NCBI Accession: NP_631915

UniProt: Q8WX94

Pathways: Inflammasome