cb629 antibody, DrZIP1 antibody, sb:cb629 antibody, zgc:111852 antibody, frzip1p antibody, zip1 antibody, zirtl antibody, ZIP1 antibody, ZIRTL antibody, Zip1 antibody, Zirtl antibody, solute carrier family 39 (zinc transporter), member 1 antibody, solute carrier family 39 member 1 antibody, solute carrier family 39 member 1 L homeolog antibody, slc39a1 antibody, Slc39a1 antibody, SLC39A1 antibody, slc39a1.L antibody
Background
ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappaB, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.Synonyms: IRT1, Solute carrier family 39 member 1, ZIP-1, ZIP1, ZIRTL, Zinc-iron-regulated transporter-like, Zrt- and Irt-like protein 1