1810013D05Rik antibody, 2010205A06Rik antibody, Zip5 antibody, LZT-Hs7 antibody, ZIP5 antibody, solute carrier family 39 member 5 antibody, solute carrier family 39 (metal ion transporter), member 5 antibody, SLC39A5 antibody, Slc39a5 antibody
Background
The zinc transporter ZIP5, also known as SLC39A5, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP5 is closely related to ZIP4, and is found in many of the same tissues, including intestine, pancreas, liver, and kidney, but unlike ZIP4, ZIP5 localizes to the basolateral membrane in kidney cells and its activity is not downregulated by zinc repletion. Recent evidence suggests that ZIP4 and ZIP5 are reciprocally regulated, with translation of ZIP5 mRNA decreasing and ZIP5 protein being rapidly internalized and degraded in response to zinc deficiency.Synonyms: Solute carrier family 39 member 5, ZIP-5, ZIP5, Zrt- and Irt-like protein 5