DNASE2 antibody (AA 25-90)
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- Target See all DNASE2 Antibodies
- DNASE2 (Deoxyribonuclease II, Lysosomal (DNASE2))
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Binding Specificity
- AA 25-90
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DNASE2 antibody is un-conjugated
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Application
- ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Human, Mouse
- Predicted Reactivity
- Rat,Dog,Cow,Sheep,Pig
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human DNase II alpha
- Isotype
- IgG
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- Application Notes
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ELISA 1:500-1000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells." in: Nature communications, Vol. 9, Issue 1, pp. 1249, (2018) (PubMed).
: "
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Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells." in: Nature communications, Vol. 9, Issue 1, pp. 1249, (2018) (PubMed).
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- Target
- DNASE2 (Deoxyribonuclease II, Lysosomal (DNASE2))
- Alternative Name
- DNase 2 alpha (DNASE2 Products)
- Synonyms
- CG7780 antibody, DNase antibody, DNase 1 antibody, DNase-1 antibody, DNase1 antibody, Dmel\\CG7780 antibody, dDNase II antibody, dnase2 antibody, MGC80103 antibody, DNASE2 antibody, LOC733868 antibody, fa92d01 antibody, wu:fa56d08 antibody, wu:fa92d01 antibody, DDBDRAFT_0188966 antibody, DDBDRAFT_0252883 antibody, DDB_0188966 antibody, DDB_0252883 antibody, Dnase2 antibody, DNASE2A antibody, DNL antibody, DNL2 antibody, Dnase2a antibody, Deoxyribonuclease II antibody, deoxyribonuclease II, lysosomal L homeolog antibody, deoxyribonuclease 2, lysosomal antibody, deoxyribonuclease II, lysosomal antibody, deoxyribonuclease II antibody, deoxyribonuclease II alpha antibody, DNaseII antibody, dnase2.L antibody, DNASE2 antibody, dnase2 antibody, Dnase2a antibody, Dnase2 antibody
- Background
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Synonyms: DNL, DNL2, DNASE2A, Deoxyribonuclease-2-alpha, Acid DNase, Deoxyribonuclease II alpha, DNase II alpha, Lysosomal DNase II, R31240_2, DNASE2
Background: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.
- Gene ID
- 1777
- UniProt
- O00115
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