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DNASE2 antibody (AA 25-90)

DNASE2 Reactivity: Human, Mouse ELISA, IF (cc), IF (p), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN872658
  • Target See all DNASE2 Antibodies
    DNASE2 (Deoxyribonuclease II, Lysosomal (DNASE2))
    Binding Specificity
    • 14
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    AA 25-90
    Reactivity
    • 38
    • 20
    • 2
    Human, Mouse
    Host
    • 36
    • 3
    Rabbit
    Clonality
    • 39
    Polyclonal
    Conjugate
    • 13
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DNASE2 antibody is un-conjugated
    Application
    • 15
    • 14
    • 12
    • 12
    • 4
    • 4
    • 3
    • 1
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse
    Predicted Reactivity
    Rat,Dog,Cow,Sheep,Pig
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human DNase II alpha
    Isotype
    IgG
  • Application Notes
    ELISA 1:500-1000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Takahashi, Loo, Okada, Kamachi, Watanabe, Wakita, Watanabe, Kawamoto, Miyata, Barber, Ohtani, Hara: "Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells." in: Nature communications, Vol. 9, Issue 1, pp. 1249, (2018) (PubMed).

  • Target
    DNASE2 (Deoxyribonuclease II, Lysosomal (DNASE2))
    Alternative Name
    DNase 2 alpha (DNASE2 Products)
    Synonyms
    CG7780 antibody, DNase antibody, DNase 1 antibody, DNase-1 antibody, DNase1 antibody, Dmel\\CG7780 antibody, dDNase II antibody, dnase2 antibody, MGC80103 antibody, DNASE2 antibody, LOC733868 antibody, fa92d01 antibody, wu:fa56d08 antibody, wu:fa92d01 antibody, DDBDRAFT_0188966 antibody, DDBDRAFT_0252883 antibody, DDB_0188966 antibody, DDB_0252883 antibody, Dnase2 antibody, DNASE2A antibody, DNL antibody, DNL2 antibody, Dnase2a antibody, Deoxyribonuclease II antibody, deoxyribonuclease II, lysosomal L homeolog antibody, deoxyribonuclease 2, lysosomal antibody, deoxyribonuclease II, lysosomal antibody, deoxyribonuclease II antibody, deoxyribonuclease II alpha antibody, DNaseII antibody, dnase2.L antibody, DNASE2 antibody, dnase2 antibody, Dnase2a antibody, Dnase2 antibody
    Background

    Synonyms: DNL, DNL2, DNASE2A, Deoxyribonuclease-2-alpha, Acid DNase, Deoxyribonuclease II alpha, DNase II alpha, Lysosomal DNase II, R31240_2, DNASE2

    Background: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.

    Gene ID
    1777
    UniProt
    O00115
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