ARHGEF7 antibody (AA 201-300) (Alexa Fluor 488)

Catalog No. ABIN883423

Product Details anti-ARHGEF7 Antibody (Alexa Fluor 488)

Target: ARHGEF7 (rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7))

Binding Specificity: AA 201-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGEF7 antibody is conjugated to Alexa Fluor 488

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ARHG7.

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ARHGEF7

Target: ARHGEF7 (rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7))

Alternative Name: ARHG7 (ARHGEF7 Products)

Synonyms: BETA-PIX antibody, COOL-1 antibody, COOL1 antibody, Nbla10314 antibody, P50 antibody, P50BP antibody, P85 antibody, P85COOL1 antibody, P85SPR antibody, PAK3 antibody, PIXB antibody, cool1 antibody, p50 antibody, p85 antibody, pak3 antibody, pixb antibody, ARHGEF7 antibody, P85spr antibody, Pak3bp antibody, Cool antibody, PIX antibody, betaPix antibody, betaPix-b antibody, betaPix-c antibody, cool-1 antibody, mKIAA0142 antibody, p85Cool1 antibody, p85SPR antibody, arhgef7 antibody, bbh antibody, bpix antibody, im:7142367 antibody, wu:fc35h08 antibody, zgc:101775 antibody, Rho guanine nucleotide exchange factor 7 antibody, Rho guanine nucleotide exchange factor 7 S homeolog antibody, ankyrin repeat domain 10 antibody, Rho guanine nucleotide exchange factor (GEF7) antibody, Rho guanine nucleotide exchange factor (GEF) 7b antibody, ARHGEF7 antibody, arhgef7.S antibody, arhgef7 antibody, ANKRD10 antibody, Arhgef7 antibody, arhgef7b antibody

Background:

Synonyms: ARHG7_HUMAN, ARHG7, ARHGEF 7, ARHGEF7, Beta pix, betaPix, betaPix-b, betaPix-c, Cool, COOL1, P50 antibody P50BP, P85, P85COOL1, P85SPR, PAK interacting exchange factor beta, PAK3, Pak3bp, PAK3BP, PIX, PIXB, Rho guanine nucleotide exchange factor GEF 7, Rho guanine nucleotide exchange factor GEF 7b, Rho guanine nucleotide exchange factor GEF7, Rho guanine nucleotide exchange factor 7, SH3 domain containing proline rich protein, Nbla10314, KIAA0142.

Background: ARHGEF7 is a p21-activated protein kinase (Pak)-interacting exchange factor that has been identified as a putative guanine nucleotide exchange factor (GEF) for Rac/Cdc42. It is expressed ubiquitously in all the tissue examined and other isoforms are expressed mainly in the central nervous system. Regulated phosphorylation of ARHGEF7 is necessary to maintain the balance between normal signalling by EGFR and Src versus aberrant growth and transformation.Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.

Gene ID: 8874

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation