C-Type Lectin Domain Family 6, Member A (CLEC6A) (AA 110-209) antibody (Alexa Fluor 350)

Catalog No. ABIN893800

Product Details

Target: C-Type Lectin Domain Family 6, Member A (CLEC6A)

Binding Specificity: AA 110-209

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Alexa Fluor 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Dectin-2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: C-Type Lectin Domain Family 6, Member A (CLEC6A)

Alternative Name: DECTIN 2 (CLEC6A Products)

Synonyms: CLEC4N antibody, CLECSF10 antibody, CLEC6A antibody, C-type lectin domain containing 6A antibody, C-type lectin domain family 6, member A antibody, CLEC6A antibody, Clec6a antibody

Background:

Synonyms: C type lectin domain family 6 member A, C type lectin superfamily member 10, C-type lectin domain family 6 member A, C-type lectin superfamily member 10, CLC6A_HUMAN, CLEC4N, Clec6a, CLECSF10, DC associated C type lectin 2, DC-associated C-type lectin 2, Dectin-2, Dectin2, Dendritic cell associated lectin 2, Dendritic cell-associated C-type lectin 2.

Background: Dectin 2 is a type II transmembrane protein that is a member of the C type lectin superfamily. In mouse, dectin 2 is predominantly expressed on tissue macrophages and some dendritic cells. Significant expression of Dectin 2 has been reported on macrophages in the red pulp and marginal zones of the spleen, kupffer cells in the liver and alveolar macrophages in the lung. Peripheral blood monocytes express low levels of dectin 2 but transient up regulation of expression has been demonstrated on monocytes at sites of inflammation. The function of dectin 2 has not been fully determined but studies suggest a possible role in immune surveillance.

Gene ID: 93978