Hexosaminidase A antibody (C-Term)

Catalog No. ABIN926663

Product Details anti-Hexosaminidase A Antibody

Target: Hexosaminidase A (HEXA)

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Hexosaminidase A antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: HEXA antibody was raised in rabbit using the C terminal of HEXA as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

HEXA Blocking Peptide, catalog no. 33R-9958, is also available for use as a blocking control in assays to test for specificity of this HEXA antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for Hexosaminidase A

Target: Hexosaminidase A (HEXA)

Alternative Name: HEXA (HEXA Products)

Synonyms: TSD antibody, fc04h11 antibody, wu:fc04h11 antibody, wu:fv09f06 antibody, si:dkey-35i22.2 antibody, HEXA antibody, Hex-1 antibody, zgc:112084 antibody, hexosaminidase subunit alpha antibody, hexosaminidase B (beta polypeptide) antibody, CUGBP Elav-like family member 6 antibody, hexosaminidase A antibody, hexosaminidase A (alpha polypeptide) antibody, beta-hexosaminidase subunit alpha-like antibody, HEXA antibody, hexb antibody, CELF6 antibody, Hexa antibody, hexa antibody, LOC100228061 antibody

Background: This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). Synonyms: Polyclonal HEXA antibody, Anti-HEXA antibody, hexosaminidase A, alpha polypeptide antibody, MGC99608 antibody, TSD antibody.

Pathways: Sensory Perception of Sound, Glycosaminoglycan Metabolic Process