GALR2 antibody (C-Term)

Catalog No. ABIN926733

Product Details anti-GALR2 Antibody

Target: GALR2 (Galanin Receptor 2 (GALR2))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GALR2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: GALR2 antibody was raised in rabbit using the C terminal of GALR2 as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

GALR2 Blocking Peptide, catalog no. 33R-10391, is also available for use as a blocking control in assays to test for specificity of this GALR2 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for GALR2

Target: GALR2 (Galanin Receptor 2 (GALR2))

Alternative Name: GALR2 (GALR2 Products)

Synonyms: GALNR2 antibody, mGalR antibody, GALR2 antibody, GAL2-R antibody, GALR-2 antibody, galanin receptor 2 antibody, transcription regulator. LacI family, raffinose related antibody, DNA-binding transcriptional regulator GalR antibody, galactose operon repressor antibody, galanin receptor type 2 antibody, GALR2 antibody, Galr2 antibody, LOC100037698 antibody, rafR antibody, galR2 antibody, LOC103690156 antibody

Background: Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. Synonyms: Polyclonal GALR2 antibody, Anti-GALR2 antibody, galanin receptor 2 antibody, GALNR2 antibody, MGC125983 antibody, MGC125984 antibody.

Pathways: cAMP Metabolic Process, Inositol Metabolic Process, Feeding Behaviour