Prothrombin Fragment 2 antibody

Catalog No. ABIN927011

Product Details

Target: Prothrombin Fragment 2

Reactivity: Human

Host: Sheep

Clonality: Polyclonal

Purification: Affinity chromatography purified

Immunogen: Prothrombin fragment 2 antibody was raised in sheep using human Prothrombin purified from plasma as the immunogen.

Isotype: IgG

Application Details

Application Notes: Optimal conditions should be determined byt he investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Supplied in liquid form with 10 mM HEPES, pH 7.4, 150 mM NaCl, 50 % (v/v) glycerol.

Handling Advice: Avoid repeated freeze/thaw cycles.
Product will become viscous but will not freeze. Avoid storage in frost-free freezers. Allow product to warm to room temperature and gently mix before use.

Storage: -20 °C

Storage Comment: Store at -10 to -20 °C.

References

Shin, Jeon, Leem, Won, Jeong, Park, McLean, Lee, Jin, Jung, Kim: "Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson's disease." in: Scientific reports, Vol. 5, pp. 14764, (2016) (PubMed).

Target Details

Target: Prothrombin Fragment 2

Background: Prothrombin is a vitamin K-dependent plasma protein which is synthesized in the liver. Prior to secretion into plasma, prothrombin undergoes post-translational modification by a vitamin K-dependent carboxylase which converts ten specific glutamic acid residues to gamma-carboxyglutamic acid (gla). The ten gla residues are located within the first 40 amino acids of the mature protein and contribute to the ability of prothrombin to bind to negatively charged phospholipid membranes. Synonyms: Polyclonal Prothrombin fragment 2 antibody, Anti-Prothrombin fragment 2 antibody.