STAT5B antibody (N-Term)

Catalog No. ABIN927756

The Rabbit Polyclonal anti-STAT5B antibody (ABIN927756) specifically detects STAT5B in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Cow, Pig, Zebrafish (Danio rerio), Chicken and Xenopus laevis samples.

Quick Overview for STAT5B antibody (N-Term) (ABIN927756)

Target: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Reactivity: Human, Mouse, Rat, Dog, Cow, Pig, Zebrafish (Danio rerio), Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAT5B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-STAT5B Antibody

Binding Specificity: N-Term

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Chicken, Pig (Porcine), Cow (Bovine), Dog (Canine), Zebrafish (Brachydanio rerio), Frog

Purification: Purified

Immunogen: STAT5 B antibody was raised in rabbit using the N terminal of STAT5 as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

STAT5B Blocking Peptide, (ABIN937008), is also available for use as a blocking control in assays to test for specificity of this STAT5B antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for STAT5B

Target: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Alternative Name: STAT5B

Background: The protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. Synonyms: Polyclonal STAT5B antibody, Anti-STAT5B antibody, signal transducer and activator of transcription 5B antibody, STAT5 antibody.

Pathways: JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation