PSME2 antibody (Middle Region)

Catalog No. ABIN928858

Product Details anti-PSME2 Antibody

Target: PSME2 (Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta) (PSME2))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSME2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: PSME2 antibody was raised in rabbit using the middle region of PSME2 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

PSME2 Blocking Peptide, catalog no. 33R-7527, is also available for use as a blocking control in assays to test for specificity of this PSME2 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for PSME2

Target: PSME2 (Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta) (PSME2))

Alternative Name: PSME2 (PSME2 Products)

Synonyms: unp309 antibody, PA28B antibody, PA28beta antibody, REGbeta antibody, AA589371 antibody, AI788882 antibody, PA28b antibody, proteasome activator subunit 2 antibody, proteasome (prosome, macropain) activator subunit 2 (PA28 beta) antibody, psme2 antibody, PSME2 antibody, Psme2 antibody

Background: An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. Synonyms: Polyclonal PSME2 antibody, Anti-PSME2 antibody, proteasome, prosome, macropain activator subunit 2, PA28 beta antibody, PA28B antibody, PA28beta antibody, REGbeta antibody.

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA