Integrin Alpha2b antibody (Biotin)

Catalog No. ABIN94107

This anti-Integrin Alpha2b antibody is a Mouse Monoclonal antibody detecting Integrin Alpha2b in FACS. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for Integrin Alpha2b antibody (Biotin) (ABIN94107)

Target: Integrin Alpha2b (CD41)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin Alpha2b antibody is conjugated to Biotin

Application: Flow Cytometry (FACS)

Clone: MEM-06

Product Details anti-Integrin Alpha2b Antibody (Biotin)

Purpose: Anti-Hu CD41 Biotin

Specificity: The antibody MEM-06 reacts with an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain, 120 kDa) and GPIIb beta (light chain, 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.

Cross-Reactivity (Details): Human

Purification: Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.

Immunogen: Leukocytes of patient suffering from LGL-type leukaemia.

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: Recommended dilution: 2 μg/mL.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze.
Avoid prolonged exposure to light.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

References for anti-Integrin Alpha2b antibody (Biotin) (ABIN94107)

Karimi, Dalirfardouei, Dias, Lötvall, Lässer: "Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma - Contributions of platelet extracellular vesicles in plasma samples." in: Journal of extracellular vesicles, Vol. 11, Issue 5, pp. e12213, (2022) (PubMed).

Target Details for Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Alternative Name: CD41

Background: Integrin subunit alpha 2b,CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.,Platelet GPIIb, Integrin alpha-IIb, GPalpha IIb, GTA

Gene ID: 3674

UniProt: P08514

Pathways: Integrin Complex