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MICA antibody

MICA Reactivity: Human, Cow, Non-Human Primate ELISA, FACS, IP Host: Mouse Monoclonal MEM-123 unconjugated
Catalog No. ABIN94335
  • Target See all MICA Antibodies
    MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
    Reactivity
    • 69
    • 17
    • 14
    • 11
    • 6
    • 5
    • 2
    • 1
    Human, Cow, Non-Human Primate
    Host
    • 37
    • 32
    Mouse
    Clonality
    • 37
    • 33
    Monoclonal
    Conjugate
    • 44
    • 8
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MICA antibody is un-conjugated
    Application
    • 45
    • 36
    • 32
    • 18
    • 17
    • 12
    • 9
    • 8
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP)
    Specificity
    The antibody MEM-123 reacts with an extracellular epitope of all human classical MHC Class I molecules (major histocompatibility complex) in native cell-surface forms as well as with human HLA-G cDNA transfected cells. MHC Class I molecules (MHC Class Ia) are expressed on the surface of all human cell types. The antibody MEM-123 completely blocks binding of classical W6/32 to surface-expressed HLA-G, but does not cross-blocks the antibody MEM-G/9.
    Cross-Reactivity (Details)
    Human, Non-Human Primates, Bovine
    Purification
    Purified by protein-A affinity chromatography.
    Purity
    > 95 % (by SDS-PAGE)
    Immunogen
    COS-7 African green monkey kidney cells
    Clone
    MEM-123
    Isotype
    IgG3
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    Discover our top product MICA Primary Antibody
  • Application Notes
    Flow cytometry: Recommended dilution: 4 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Target
    MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
    Alternative Name
    HLA-Class I (MICA Products)
    Synonyms
    MIC-A antibody, PERB11.1 antibody, MHC class I polypeptide-related sequence A antibody, MICA antibody
    Background
    HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules.
    Pathways
    Activation of Innate immune Response, Transition Metal Ion Homeostasis
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