BMP7 antibody (AA 316-431)
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- Target See all BMP7 Antibodies
- BMP7 (Bone Morphogenetic Protein 7 (BMP7))
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Binding Specificity
- AA 316-431
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This BMP7 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Specificity
- Recognizes Human BMP7.
- Cross-Reactivity (Details)
- Species reactivity (tested):Human.
- Purification
- Protein A Chromatography
- Immunogen
- Highly pure (>95%) recombinant Human BMP-7 (Ala316-His431) derived from E. coli.
- Isotype
- IgG
- Top Product
- Discover our top product BMP7 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Reconstitution
- Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
- Buffer
- PBS, pH 7.2
- Storage
- 4 °C/-20 °C
- Storage Comment
- The lyophilized antibody is stable at RT for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C. Avoid repeated freeze-thaw cycles!
- Expiry Date
- 6 months
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- Target
- BMP7 (Bone Morphogenetic Protein 7 (BMP7))
- Alternative Name
- BMP7 (BMP7 Products)
- Synonyms
- bmp-7 antibody, bmp7 antibody, op-1 antibody, BMP7 antibody, zgc:153025 antibody, OP-1 antibody, OP1 antibody, BMP-7 antibody, fb83f09 antibody, wu:fb83f09 antibody, bone morphogenetic protein 7 antibody, bone morphogenetic protein 7, gene 1 L homeolog antibody, bone morphogenetic protein 7b antibody, bone morphogenetic protein 7, gene 2 L homeolog antibody, bone morphogenetic protein 7a antibody, BMP7 antibody, bmp7.1.L antibody, LOC100136282 antibody, bmp7b antibody, Bmp7 antibody, LOC100008826 antibody, bmp7.2.L antibody, bmp7a antibody
- Background
- Bone morphogenetic protein 7 (BMP-7), also known as osteogenic protein 1 (OP1), is a widely expressed TGFβ superfamily member with important functions during embryogenesis, in the adult, and in disease (1,2). Human BMP-7 is synthesized with a 29 amino acid (aa) signal sequence, a 263 aa propeptide, and a 139 aa growth factor domain (3). The growth factor domain of human BMP-7 shares 98 % aa sequence identity with mouse and rat BMP-7. The BMP-7 propeptide is cleaved intracellularly but often remains associated with the mature C-terminus. Based on in vivo and in vitro studies, BMP-7 has the potential to be secreted as a disulfide-linked mature homodimer, or particularly as a heteromeric complex that consists of two propeptides noncovalently associated with a mature disulfide linked homodimer (5,6). The presence of the propeptides in BMP-7 appears to stabilize the molecule and provide a docking mechanism for extracellular storage on molecules such as fibrillin1 and 2 (5,6). The propeptides themselves do not impart latency to the complex. BMP-7 binding to type II receptors rapidly displaces the prodomain: mature molecule interaction and has no effect on activity. But it is suggested that immobilized BMP-7 (via prodomain:fibrillin) is inactive, allowing for possible long term storage of the molecule (6). BMP-7 interacts with the type 2 receptors Activin RIIA, Activin RIIB, and BMPRII and the type 1 receptors Activin RIA, BMPRIA, and BMPRIB (2,6). BMP-7 may also be processed into a disulfide-linked heterodimer with either BMP-2 or BMP-4. Such complexes may show increased potency and range of activity compared to BMP7 homodimers (7-9). BMP-7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development (10,11), inhibits the branching of prostate epithelium (12), and antagonizes epithelial mesenchymal transition (EMT) (13-15). In pathological conditions, BMP-7 inhibits tumor growth and metastasis (14), ameliorates fibrotic damage in nephritis (13), and promotes neuro regeneration following brain ischemia (16).Synonyms: BMP-7, Bone morphogenetic protein 7, OP1, Osteogenic protein 1
- Gene ID
- 655
- NCBI Accession
- NP_001710
- Pathways
- Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance
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