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Myeloid Lineage antibody

Reactivity: Rat FACS, IHC (fro), WB Host: Mouse Monoclonal OX-82 unconjugated
Catalog No. ABIN953567
  • Target
    Myeloid Lineage
    Reactivity
    Rat
    Host
    • 3
    Mouse
    Clonality
    • 3
    Monoclonal
    Conjugate
    • 1
    • 1
    • 1
    Un-conjugated
    Application
    Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
    Cross-Reactivity (Details)
    Species reactivity (tested):Rat.
    Purification
    Protein G Chromatography of Ascites fluid.
    Immunogen
    Anemic Rat bone marrow.
    Clone
    OX-82
    Isotype
    IgG1
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in alqiuots) at -20 °C for longer.
  • Target
    Myeloid Lineage
    Background
    Hematopoietic stem cells (HSC) are the precursor cells found in the bone marrow which give rise to all the blood cell types of both the Myeloid and lymphoid lineages, which include monocytes and macrophages, neutrophils, basophils, eosinophils, T cells, B cells, NK cells, microglia, erythrocytes, megakaryocytes and dendritic cells. During the process of hematopoiesis, Myeloid lineage cells originate from the bone marrow, while Lymphoid lineage cells originate from the lymph tissue. Blimp-1 is a key regulator of the differentiation of the separate hematopoietic myeloid and lymphoid lineages. The distinction between myeloid and lymphoid lineages is essential to diagnose and treat certain cancers. Myeloid lineage cells induce inflammatory cytokine production upon activation by Kaposi's sarcoma-associated herpesvirus OX2 glycoprotein. At the stage of myelocytes, Myeloid lineage cells express a substantial number of IL-8 receptor homologs.
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