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Importin 8 antibody (C-Term)
IPO8
Reactivity: Human, Dog, Cow, Pig
IHC (p), EIA
Host: Goat
Polyclonal
unconjugated
Product Details anti-Importin 8 Antibody
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Target
See all Importin 8 (IPO8) Antibodies
Importin 8 (IPO8)
Binding Specificity
All epitopes for Importin 8 antibodies
C-Term
Reactivity
All reactivities for Importin 8 antibodies
Human, Dog, Cow, Pig
Host
All hosts for Importin 8 antibodies
Goat
Clonality
All clonalities for Importin 8 antibodies
Polyclonal
Conjugate
All conjugates for Importin 8 antibodies
This Importin 8 antibody is un-conjugated
Application
All applications for Importin 8 antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Sequence
C-SAFNFGTVPS NN
Specificity
This antibody is expected to recognise isoform 1 (NP_006381.2) and isoform 2 (NP_001177924.1).
Cross-Reactivity (Details)
Species reactivity (expected):Dog, Pig, Cow. Species reactivity (tested):Human.
Purification
Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Immunogen
Peptide with sequence from the C-Terminus of the protein sequence according to NP_006381.2, NP_001177924.1. Genename: IPO8
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for Importin 8
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Target
Importin 8 (IPO8)
Alternative Name
RanBP8 / Importin-8 (IPO8 Products )
Synonyms
IPO8 antibody, si:ch211-116i17.1 antibody, RANBP8 antibody, 6230418K12Rik antibody, Abcc10 antibody, C130009K11Rik antibody, MRP7 antibody, OM-1 antibody, Om1 antibody, Ranbp8 antibody, importin 8 antibody, IPO8 antibody, ipo8 antibody, Ipo8 antibody
Background
Importin 8 is a 1037 amino acid nuclear protein with a RAN binding site. It belongs to RAN-binding protein super family and hence shares an N-terminal sequence motif with importin-beta that appears to account for RAN GTP binding. It binds to the nuclear pore complex (NPC) and is well known as a transport carrier that mediates nuclear import of ribosomal proteins with a classical nuclear localization signal. Importin 8 works by binding to the nuclear pore complex and, along with RANGTP and RANBP1, inhibits the GAP stimulation of the RAN GTPase. Along with transportin it also helps in the nuclear import of SRP19.Synonyms: IMP8, IPO8, RAN binding protein 8
Gene ID
10526
NCBI Accession
NP_006381
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