ADAMTS1 antibody (C-Term)

Catalog No. ABIN965511

Product Details anti-ADAMTS1 Antibody

Target: ADAMTS1 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 1 (ADAMTS1))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAMTS1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of mouse ADAMTS-1(A disintegrin and metalloproteinase with thrombospondin motifs 1)

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for ADAMTS1

Target: ADAMTS1 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 1 (ADAMTS1))

Alternative Name: ADAMTS-1 (ADAMTS1 Products)

Synonyms: c3-c5 antibody, meth1 antibody, xadamts1 antibody, C3-C5 antibody, METH1 antibody, ADAM-TS1 antibody, ADAMTS antibody, ADAMTS-1 antibody, METH-1 antibody, adamts1 antibody, ADAM metallopeptidase with thrombospondin type 1 motif 1 antibody, ADAM metallopeptidase with thrombospondin type 1 motif, 1 antibody, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 antibody, ADAM metallopeptidase with thrombospondin type 1 motif 1 L homeolog antibody, ADAMTS1 antibody, adamts1 antibody, Adamts1 antibody, adamts1.L antibody

Background: ADAM-TS1 (A disintegrin and metalloproteinase with thrombospondin motifs 1) cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. ADAM-TS1 has angiogenic inhibitor activity. Active metalloprotease may be associated with various inflammatory processes as well as development of cancer cachexia. ADAM-TS1 may play a critical role in follicular rupture. ADAM-TS1 cleaves aggrecan at the 1691-Glu-|-Leu1692 site, within the chondroitin sulfate attachment domain. It binds 1 zinc ion per subunit. ADAM-TS1 is a secreted protein and is associated with the extracellular matrix.It is induced in vitro in colon adenocarcinoma cells by interleukin-1, or in vivo in kidney and heart by lipopolysaccharide and it is also induced by LH stimulation in granulose cells of preovulatory follicles. The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. The precursor is cleaved by a furin endopeptidase. ADAM-TS1 contains 1 disintegrin domain, 1 peptidase M12B domain, and 3 TSP type-1 domains.

Pathways: SARS-CoV-2 Protein Interactome