ATM antibody (Ataxia Telangiectasia Mutated)

Details for Product anti-ATM Antibody No. ABIN965618, Supplier: Log in to see
Antigen
  • ATM
  • Atm
  • CG6535
  • Dmel\\CG6535
  • Tefu
  • atm
  • atm/tefu
  • dATM
  • tef
  • Xatm
  • at1
  • atdc
  • tel1
  • telo1
  • AT1
  • ATA
  • ATC
  • ATD
  • ATDC
  • ATE
  • TEL1
  • TELO1
  • AI256621
  • C030026E19Rik
  • telomere fusion
  • ATM serine/threonine kinase L homeolog
  • ATM serine/threonine kinase
  • ataxia telangiectasia mutated
  • ataxia telangiectasia mutated (atm)
  • serine/threonine-protein kinase ATM
  • tefu
  • atm.L
  • atm
  • ATM
  • EDI_100660
  • CpipJ_CPIJ001772
  • BDBG_08252
  • PAAG_02532
  • MCYG_05088
  • VDBG_06833
  • ACLA_015700
  • LOC5565620
  • MGYG_07634
  • PGTG_14279
  • Atm
Alternatives
anti-Hamster ATM antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
368
161
83
28
8
1
1
Host
Mouse
248
102
11
8
3
1
Clonality (Clone)
Monoclonal ()
Conjugate
This ATM antibody is un-conjugated
11
11
9
8
7
6
5
5
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
ELISA, Western Blotting (WB)
233
137
121
96
82
57
53
45
27
22
13
8
4
4
2
2
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Purified recombinant fragment of human ATM expressed in E. Coli.
Clone 5C5
Isotype IgG1
Purification Ascitic fluid
Plasmids, Primers & others Plasmids, Primers & others ATM products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name ATM (ATM Antibody Abstract)
Background The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.
Synonyms: AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, MGC74674, DKFZp781A0353, ATM
Molecular Weight 351kDa
Gene ID 472
Pathways p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Background publications Smirnov, Cheung: "ATM gene mutations result in both recessive and dominant expression phenotypes of genes and microRNAs." in: American journal of human genetics, Vol. 83, Issue 2, pp. 243-53, 2008 (PubMed).

Product cited in: Goodarzi, Noon, Deckbar, Ziv, Shiloh, Löbrich, Jeggo: "ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin." in: Molecular cell, Vol. 31, Issue 2, pp. 167-77, 2008 (PubMed).

ORegan, Kiely, OGara: "Expression of the adenyl cyclase-encoding gene (cya) of Rhizobium meliloti F34: existence of two cya genes?" in: Gene, Vol. 83, Issue 2, pp. 243-9, 1990 (PubMed).

Renkawitz, Beug, Graf, Matthias, Grez, Schütz: "Expression of a chicken lysozyme recombinant gene is regulated by progesterone and dexamethasone after microinjection into oviduct cells." in: Cell, Vol. 31, Issue 1, pp. 167-76, 1983 (PubMed).

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