CAPN1 antibody (AA 312-326)
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- Target See all CAPN1 Antibodies
- CAPN1 (Calpain 1 (CAPN1))
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Binding Specificity
- AA 312-326
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Reactivity
- Human, Mouse, Rat
- Host
- Please inquire
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Clonality
- Polyclonal
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Conjugate
- This CAPN1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Immunogen
- A synthetic peptide corresponding to a sequence at the middle region of human Calpain-1 (312-326 aa), different from the mouse sequence by two amino acids.
- Top Product
- Discover our top product CAPN1 Primary Antibody
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- Restrictions
- For Research Use only
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- Reconstitution
- 0.2ml of distilled water will yield a concentration of 500µg/ml.
- Buffer
- Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
- Preservative
- Thimerosal (Merthiolate), Sodium azide
- Storage
- -20 °C
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Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease." in: Biochemistry, Vol. 27, Issue 21, pp. 8122-8, (1989) (PubMed).
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Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease." in: Biochemistry, Vol. 27, Issue 21, pp. 8122-8, (1989) (PubMed).
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- Target
- CAPN1 (Calpain 1 (CAPN1))
- Alternative Name
- Calpain 1 (CAPN1 Products)
- Synonyms
- CAPN1 antibody, Capa-1 antibody, Capa1 antibody, mu-calpin antibody, Capn1 antibody, fj67g01 antibody, wu:fj67g01 antibody, calpain 1 antibody, zgc:55262 antibody, CAPN1 antibody, Capn1 antibody, zgc:55262 antibody
- Background
- Calpain-1 catalytic subunit is a protein that in humans is encoded by the CAPN1 gene. Calpain is an intracellular protease that requires calcium for its catalytic activity. Two isozymes, calpain I (mu-calpain) and calpain II (m-calpain), with different calcium requirements, have been identified. Both are heterodimers composed of L (large, catalytic, 80 kD) and S (small, regulatory, 30 kD) subunits. The isozymes share an identical S subunit, with the differences arising from the L subunits, L1 (CAPN1) and L2. By quantitative RT-PCR, Ueyama et al. (1998) found that expression of calpain-1 and calpain-2 mRNA was significantly increased in muscle biopsy samples derived from 5 men with progressive muscular dystrophy (e.g., DMD, 310200) and 2 men and 3 women with amyotrophic lateral sclerosis (ALS, 105400) compared with controls. Using cDNA clones as probes, Ohno et al. (1989, 1990) assign CANPL1 to chromosome 11.
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