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GSK3 alpha antibody

GSK3a Reactivity: Human WB, ELISA Monoclonal unconjugated
Catalog No. ABIN966231
  • Target See all GSK3 alpha (GSK3a) Antibodies
    GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))
    Reactivity
    • 104
    • 84
    • 66
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Human
    Host
    Please inquire
    Clonality
    • 113
    • 29
    Monoclonal
    Conjugate
    • 76
    • 11
    • 10
    • 8
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GSK3 alpha antibody is un-conjugated
    Application
    • 113
    • 65
    • 58
    • 21
    • 20
    • 16
    • 13
    • 13
    • 7
    • 3
    • 3
    • 3
    • 2
    Western Blotting (WB), ELISA
    Specificity
    Ni-NTA purified truncated recombinant GSK3 alpha expressed in E. Coli strain BL21 (DE3)
    Purification
    Crude ascites.
    Isotype
    IgG1
    Top Product
    Discover our top product GSK3a Primary Antibody
  • Application Notes
    Western Blot: 1: 500- 1: 2,000
    ELISA: Propose dilution 1: 10,000.
    Determining optimal working dilutions by titration test.
    Restrictions
    For Research Use only
  • Storage
    -20 °C
  • Mendez, Garcia-Segura: "Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells." in: Endocrinology, Vol. 147, Issue 6, pp. 3027-39, (2006) (PubMed).

    Bianchi, De Lucchini, Marin, Turner, Hanks, Villa-Moruzzi: "Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration." in: The Biochemical journal, Vol. 391, Issue Pt 2, pp. 359-70, (2005) (PubMed).

    De Servi, Hermani, Medunjanin, Mayer: "Impact of PKCdelta on estrogen receptor localization and activity in breast cancer cells." in: Oncogene, Vol. 24, Issue 31, pp. 4946-55, (2005) (PubMed).

  • Target
    GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))
    Alternative Name
    GSK3 alpha (GSK3a Products)
    Synonyms
    2700086H06Rik antibody, GSK3A antibody, GSK-3[a] antibody, GSK-3[b] antibody, GSK3 antibody, gsk3a antibody, xgsk3 antibody, glycogen synthase kinase 3 alpha antibody, glycogen synthase kinase 3 alpha b antibody, glycogen synthase kinase 3 alpha S homeolog antibody, GSK3A antibody, Gsk3a antibody, gsk3a antibody, gsk3ab antibody, gsk3a.S antibody, Bm1_31380 antibody
    Background
    : Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily,GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.
    Gene ID
    11076
    Pathways
    PI3K-Akt Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, BCR Signaling, Warburg Effect
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