IGFBP2
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Western Bloting: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test.
Restrictions
For Research Use only
Format
Liquid
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Stewart, Weigel: "Role of insulin-like growth factor binding proteins in 1alpha,25-dihydroxyvitamin D(3)-induced growth inhibition of human prostate cancer cells." in: The Prostate, Vol. 64, Issue 1, pp. 9-19, (2005) (PubMed).
Fisher, Meyer, Garber, Dealy: "Role of IGFBP2, IGF-I and IGF-II in regulating long bone growth." in: Bone, Vol. 37, Issue 6, pp. 741-50, (2005) (PubMed).
Miyake, Hara, Yamanaka, Muramaki, Gleave, Eto: "Introduction of insulin-like growth factor binding protein-2 gene into human bladder cancer cells enhances their metastatic potential." in: Oncology reports, Vol. 13, Issue 2, pp. 341-5, (2005) (PubMed).
Target
IGFBP2
(Insulin-Like Growth Factor Binding Protein 2, 36kDa (IGFBP2))
IGFBP2: insulin-like growth factor binding protein 2. IGFBP2 is a member of the ISGBP family which bind various IGFs. IGFBP2 is overexpressed in a wide spectrum of other cancers, including glioma, prostate cancer, synovial sarcoma, neuroblastoma, colon cancer, adrenocortical cancer, lung cancer, Wilms' tumor, and hepatoblastoma. The overexpression of IGFBP2 also correlates with the aggressiveness of some tumors. IGFBP2 activates the expression of matrix metalloprotease 2, which contributes to cell invasiveness. Synonyms: IBP2, IGF-BP53