LCavB1 (N-Term) antibody

Catalog No. ABIN966479

Product Details

Target: LCavB1

Binding Specificity: N-Term

Reactivity: Great Pond Snail (Lymnaea stagnalis)

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of Great Pond Snail (Lymnaea stagnalis) LCavB1 (Voltage-Dependent Calcium Channel Beta Subunit)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References

Spafford, Van Minnen, Larsen, Smit, Syed, Zamponi: "Uncoupling of calcium channel alpha1 and beta subunits in developing neurons." in: The Journal of biological chemistry, Vol. 279, Issue 39, pp. 41157-67, (2004) (PubMed).

Spafford, Munno, Van Nierop, Feng, Jarvis, Gallin, Smit, Zamponi, Syed: "Calcium channel structural determinants of synaptic transmission between identified invertebrate neurons." in: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 4258-67, (2003) (PubMed).

Target Details

Target: LCavB1

Background: LCavB1 (Voltage-Dependent Calcium Channel Beta Subunit) contains the region 1 of high conservation among beta subunits, Src homology 3 domains. SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs, they play a role in the regulation of enzymes by intramolecular interactions and changing the subcellular localization. LCavB1 contains the region 2 of high conservation among beta subunits, beta subunit interaction domain (BID) as well as Dihydropyridine sensitive L-type calcium channel(Beta subunit) which is conserved region among calcium channel beta subunits and Guanylate kinase homologues, a region is similar to guanylate kinase